Abundant mineral resources could promote regional economic growth. However irrational exploitation of mineral resources may bring about various environmental, economic, social problems. This paper analyzes the adverse effects of the exploitation of mineral resources on environment, economy and society, with some practical examples of China’s western regions, and makes suggestions on how to escape the detrimental impacts. The solutions that are given include achieving sustainable development, promoting green mining, considering the benefits of the majority of local residuals, enhancing international exchanges and other related measures.